Abstract Diiminosuccinonitrile (DISN), formed by the oxidation of diaminomaleonitrile (DAMN), has been investigated as a potential prebiotic phosphorylating agent. DISN effects the cyclization of 3′-adenosine monophosphate to adenosine 2′, 3′-cyclic phosphate in up to 39% yield. The mechanism of this reaction was investigated. The DISN-mediated phosphorylation of uridine to uridine monophosphate does not proceed efficiently in aqueous solution. The reaction of DISN with uridine-5′-phosphate and uridine results in the formation of 2,2′-anhydronucleotides and 2,2′-anhydronucleosides respectively, and other reaction products resulting from an initial reaction at the 2′- and 3′-hydroxyl groups. The clay mineral catalysis of the cyclization of adenosine-3′-phosphate was investigated using homoionic montmorillonites.


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    Titel :

    The prebiotic chemistry of nucleotides


    Beteiligte:
    Ferris, J. P. (Autor:in) / Yanagawa, H. (Autor:in) / Hagan, W. J. (Autor:in)

    Erschienen in:

    Erscheinungsdatum :

    1984




    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Print


    Sprache :

    Englisch



    Klassifikation :

    Lokalklassifikation TIB:    535/3908/4290
    BKL:    44.71 Verkehrsmedizin



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