Abstract An evolutionary scheme is postulated in which the bases enter the genetic code in a definite temporal sequence and the correlated amino acids are assigned definite functions in the evolving system. The scheme requires a singlet code (guanine coding for glycine) evolving into a doublet code (guanine-cytosine doublet coding for gly (GG), ala (GC), arg (CG), pro (CC)). The doublet code evolves into a triplet code. Polymerization of nucleotides is thought to have been by block polymerization rather than by a template mechanism. The proteins formed at first were simple structural peptides. No direct nucleotide-amino acid stereo-chemical interaction was required. Rather an adaptor-type indirect mechanism is thought to have been functioning since the origin.
Speculations on the evolution of the genetic code
Origins of life ; 6 , 3 ; 423-427
1975
Aufsatz (Zeitschrift)
Englisch
BKL: | 44.71 Verkehrsmedizin | |
Lokalklassifikation TIB: | 535/3908/4290 |
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|GWLB - Gottfried Wilhelm Leibniz Bibliothek | 1977
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