Shedding of Epstein-Barr virus (EBV) by astronauts before, during, and after space shuttle missions was quantified. Of 1398 saliva specimens from 32 astronauts, 314 (23%) were positive for EBV DNA by PCR analysis. Of the saliva specimens collected before flight, 29% were positive for EBV DNA and of those collected during or after flight, 16% were EBV-positive. The number of EBV DNA copies from samples taken during the flight was 417+/-31, significantly higher (P < 0.05) than the number of copies from the preflight (40+/-1.7) and postflight (44+/-5) phases. Eighteen control subjects shed EBV DNA with a frequency of 3.7% and a copy number of 40+/-2 per ml saliva. Ten days before flight and on landing day, antibody titers to EBV viral capsid antigen (VCA) were significantly (P < 0.05) higher than baseline levels. On landing day, urinary level of cortiso1 and catecholamines, and plasma levels of substance P and other neuropeptides, were increased over their preflight value. Results suggested that stress associated with spaceflight decreases cellular immunity and thereby leads to increased viral reactivation.


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    Titel :

    Increased EBV Shedding in Astronaut Saliva During Spaceflight


    Beteiligte:
    Pierson, D. L. (Autor:in) / Stowe, R. P. (Autor:in) / Phillips, T. (Autor:in) / Lugg, D. J. (Autor:in) / Mehta, S. K. (Autor:in)

    Erscheinungsdatum :

    2003-01-01


    Medientyp :

    Preprint


    Format :

    Keine Angabe


    Sprache :

    Englisch


    Schlagwörter :


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