The study of physiological changes during spaceflight, and the pursuit of remedies to counteract those changes, often requires unique research protocols that lead to unexpected findings; some with important clinical implications. In our research into the development of treatments to counteract the detrimental cardiovascular effects of spaceflight, we have discovered an important drug interaction between promethazine and midodrine.


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    Titel :

    Midodrine Exacerbates Promethazine-induced Akathisia


    Beteiligte:
    Platts, Steven H. (Autor:in) / Shi, Shang-Jin (Autor:in) / Meck, Janice V. (Autor:in)

    Erscheinungsdatum :

    01.01.2006


    Medientyp :

    Preprint


    Format :

    Keine Angabe


    Sprache :

    Englisch


    Schlagwörter :


    Bioavailability of Promethazine during Spaceflight

    Boyd, Jason L. / Wang, Zuwei / Putcha, Lakshmi | NTRS | 2009


    Midodrine prevents orthostatic intolerance associated with simulated spaceflight

    Ramsdell, C. D. / Mullen, T. J. / Sundby, G. H. et al. | NTRS | 2001


    Midodrine as a Countermeasure for Post-spaceflight Orthostatic Hypotension

    Platts, Steven H. / Ziegler, Michael G. / Waters, Wendy W. et al. | NTRS | 2007



    Hemodynamic Effects of Midodrine After Space Flight in Astronauts Without Orthostatic Hypotension

    Platts, Steven H. / Ziegler, Michael G. / Waters, Wendy W. et al. | NTRS | 2006