The Rhesus monkey has been proposed as a model for the effects of space flight on immunity. In order to determine the feasibility of the use of the Rhesus monkey as a model, we studied the use of Rhesus monkey cells for immunological procedures that have been shown to be affected by space flight in both rodents and humans. We have shown that both lymph node cells and peripheral blood leukocytes can be stained with monoclonal antibodies to detect the following surface markers: CD4, CD-8, Ia and surface immunoglobulin. Also, the level of Ia antigen expression was increased by treatment of the cells with human interferon-gamma. In addition, cells were induced to produce interferons and interleukins. Isolated neutrophils also demonstrated increased oxidative burst. These data indicate that the Rhesus monkey will be a useful model for space flight studies of immunity.


    Zugriff

    Zugriff über TIB

    Verfügbarkeit in meiner Bibliothek prüfen


    Exportieren, teilen und zitieren



    Titel :

    The Rhesus monkey as a model for testing the immunological effects of space flight


    Beteiligte:
    Sonnenfeld, G. (Autor:in) / Schaffar, L. (Autor:in) / Schmitt, D. A. (Autor:in) / Peres, C. (Autor:in) / Miller, E. S. (Autor:in)


    Erscheinungsdatum :

    1994-08-01




    Medientyp :

    Sonstige


    Format :

    Keine Angabe


    Sprache :

    Englisch


    Schlagwörter :


    The rhesus monkey as a model for testing the immunological effects of space flight

    Sonnenfeld, G. / Schaffar, L. / Schmitt, D.A. et al. | Elsevier | 1994


    The Rhesus Monkey as a Model for Testing the Immunological Effects of Space Flight

    Sonnenfeld, G. / Schaffar, L. / Schmitt, D. A. et al. | British Library Conference Proceedings | 1994



    Spaceflight and growth effects on muscle fibers in the rhesus monkey

    Bodine-Fowler, Sue C. / Roy, Roland R. / Rudolph, William et al. | NTRS | 1992