Retrospective and ongoing analyses of clinical records from 347 primary intraocular melanoman patients treated with helium ions at Lawrence Berkeley Laboratory (LBL) will allow examination of the exposure-response data for human cataract; which is a complication of the therapy from incidental exposure of the lens. Direct particle beam traversal of at least a portion of the lens usually is unavoidable in treatment of posterior intraocular tumors. The precise treatment planned for each patient permits quantitative assessment of the lenticular dose and its radiation quality. We are reporting our preliminary results on the development of helium-ion-induced lens opacifications and cataracts in 54 of these patients who had 10% or less of their lens in the treatment field. We believe these studies will be relevant to estimating the human risk for cataract in space flight.


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    Titel :

    Helium-ion-induced human cataractogenesis


    Beteiligte:
    Blakely, E. A. (Autor:in) / Daftari, I. K. (Autor:in) / Meecham, W. J. (Autor:in) / Alonso, L. C. (Autor:in) / Collier, J. M. (Autor:in) / Kroll, S. M. (Autor:in) / Gillette, E. L. (Autor:in) / Lee, A. C. (Autor:in) / Lett, J. T. (Autor:in) / Cox, A. B. (Autor:in)


    Erscheinungsdatum :

    1994-10-01



    Medientyp :

    Sonstige


    Format :

    Keine Angabe


    Sprache :

    Englisch


    Schlagwörter :


    Helium-ion-induced human cataractogenesis

    Blakely, E.A. / Daftari, I.K. / Meecham, W.J. et al. | Elsevier | 1994


    Helium-Ion-Induced Human Cataractogenesis

    Blakely, E.A. | Online Contents | 1994


    Cataractogenesis from high-LET radiation and the Casarett model

    Cox, A.B. / Lee, A.C. / Lett, J.T. et al. | Elsevier | 1983


    Cataractogenesis from high-LET radiation and the Casarett model

    Cox, A. B. / Lee, A. C. / Lett, J. T. et al. | NTRS | 1983


    Late cataractogenesis in primates and lagomorphs after exposure to particulate radiations

    Cox, A.B. / Lee, A.C. / Williams, G.R. et al. | Elsevier | 1991