The hypothesis that vestiges of the ancestral RNA-dependent RNA polymerase involved in the replication of RNA genomes of Archean cells are present in the eubacterial RNA-polymerase beta-prime subunit and its homologues is discussed. It is shown that, in the DNA-dependent RNA polymerases from three cellular lineages, a very conserved sequence of eight amino acids, also found in a small RNA-binding site previously described for the E. coli polynucleotide phosphorylase and the S1 ribosomal protein, is present. The optimal conditions for the replicase activity of the avian-myeloblastosis-virus reverse transcriptase are presented. The evolutionary significance of the in vitro modifications of substrate and template specificities of RNA polymerases and reverse transcriptases is discussed.
The origin and early evolution of nucleic acid polymerases
Advances in Space Research ; 12 , 4 19
1992-01-01
Sonstige
Keine Angabe
Englisch
The origin and early evolution of nucleic acid polymerases
Elsevier | 1991
|Specificity of protein — Nucleic acid interaction and the biochemical evolution
Online Contents | 1984
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