Abstract The hypothesis that vestiges of the ancestral RNA-dependent RNA polymerase involved in the replication of RNA genomes of Archean cells are present in the cubacterial RNA polymerase β′ subunit and its homologues is discussed. We show that in the DNA-dependent RNA polymerases from the three cellular lineages a very conserved sequence of eight amino acids also found in a small RNA-binding site previously described for the E. coli polynucleotide phosphorylase and the S1 ribosomal protein is present. The optimal conditions for the replicase activity of the avian myeloblastosis virus reverse transcriptase are presented. The evolutionary significance of the in vitro modifications of substrate and template specificities of RNA polymerases and reverse transcriptases is also discussed.


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    Titel :

    The origin and early evolution of nucleic acid polymerases


    Beteiligte:
    Lazcano, A. (Autor:in) / Llaca,, V. (Autor:in) / Cappello, R. (Autor:in) / Valverde, V. (Autor:in) / Oro, J. (Autor:in)

    Erschienen in:

    Advances in Space Research ; 12 , 4 ; 207-216


    Erscheinungsdatum :

    1991-01-01


    Format / Umfang :

    10 pages




    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch



    The origin and early evolution of nucleic acid polymerases

    Lazcano, A. / Cappello, R. / Valverde, V. et al. | NTRS | 1992





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