Quantitative data were collected on dose-response curves of cultured mouse-embryo cells (C3H10T1/2) irradiated with heavy ions of various charges and energies. Results suggests that two breaks formed on DNA within 80 A may cause cell transformation and that two DNA breaks formed within 20 A may be lethal. From results of experiments with restriction enzymes which produce DNA damages at specific sites, it was found that DNA double strand breaks are important primary lesions for radiogenic cell transformation and that blunt-ended double-strand breaks can form lethal as well as transformational damages due to misrepair or incomplete repair in the cell. The RBE-LET relationship for high-LET radiation is similar to that for HGPRT locus mutation, chromosomal deletion, and cell transformation, indicating that common lesions may be involved in these radiation effects.


    Zugriff

    Zugriff über TIB

    Verfügbarkeit in meiner Bibliothek prüfen


    Exportieren, teilen und zitieren



    Titel :

    Neoplastic cell transformation by high-LET radiation - Molecular mechanisms


    Beteiligte:


    Erscheinungsdatum :

    1989-01-01



    Medientyp :

    Sonstige


    Format :

    Keine Angabe


    Sprache :

    Englisch




    Neoplastic cell transformation by high-LET radiation: Molecular mechanisms

    Chui-hsu Yang, Tracy / Craise, Laurie M. / Mei, Man-tong et al. | Elsevier | 1989


    Dose protraction studies with low- and high-LET radiations on neoplastic cell transformation in vitro

    Yang, Tracy Chui-hsu / Craise, Laurie M. / Mei, Man-tong et al. | Elsevier | 1987


    Dose protraction studies with low- and high-LET radiations on neoplastic cell transformation in vitro

    Yang, Tracy Chui-Hsu / Craise, Laurie M. / Tobias, Cornelius A. et al. | NTRS | 1986