The potential of diiminosuccinonitrile (DISN) as a prebiotic phosphorylating agent is studied. This compound is formed readily by the oxidation of diaminomaleonitrile, a tetramer of HCN. DISN is shown to produce the cyclization of 3'-adenosine monophosphate to adenosine 2',3'-cyclic phosphate in up to 40 percent yield. The DISN-mediated phosphorylation of uridine to uridine monophosphate is determined not to proceed efficiently in aqueous solution. The reaction of DISN and BrCN with uridine-5'-phosphate and uridine is found to result in the formation of 2,2'-anhydronucleotides and 2,2'-anhydronucleosides, respectively, and other reaction products resulting from an initial reaction at the 2' and 3'-hydroxyl groups. Homoionic montmorillonites were employed to study the clay mineral catalysis of the cyclization of adenosine-3'-phosphate.


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    Titel :

    Prebiotic synthesis and reactions of nucleosides and nucleotides


    Beteiligte:
    Ferris, J. P. (Autor:in) / Yanagawa, H. (Autor:in) / Hagan, W. J., Jr. (Autor:in)

    Erscheinungsdatum :

    1983-01-01



    Medientyp :

    Sonstige


    Format :

    Keine Angabe


    Sprache :

    Englisch


    Schlagwörter :


    Prebiotic synthesis and reactions of nucleosides and nucleotides

    Ferris, J.P. / Yanagawa, H. / Hagan, W.J. Jr. | Elsevier | 1983


    The prebiotic chemistry of nucleotides

    Ferris, J. P. / Yanagawa, H. / Hagan, W. J. | Online Contents | 1984


    Prebiotic phosphorylation of nucleosides in formamide

    Schoffstall, Allen M. | Online Contents | 1976


    Interactions between amino acids and nucleotides in the prebiotic milieu

    Saxinger, Carl / Ponnamperuma, Cyril | Online Contents | 1974


    Prebiotic Synthesis of Nucleotides at the Earth Orbit in Presence of Lunar Soil

    Kuzicheva, E. A. / Gontareva, N. B. / The Committee on Space Research | British Library Conference Proceedings | 2002