Mice deprived of water for 24 h showed an increase in hematocrit and loss of body weight comparable to that seen in men during space flight. The increase in hematocrit was entirely due to a decrease in plasma volume and was associated with suppression of erythropoiesis, but with no significant change in the serum titer of a presumptive humoral regulator of erythropoiesis, Erythroid Stimulating Activity (ESA). Mice deprived of water for 24 h may be a useful model for the study of the early hematological effects of space flight. The suppression of erythropoiesis due to a relative erythrocytosis appears to be independent of ESA.


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    Titel :

    Effect of dehydration on erythropoiesis in mice - Relevance to the 'anemia' of space flight


    Beteiligte:
    Dunn, C. D. R. (Autor:in)

    Erscheinungsdatum :

    01.08.1978


    Medientyp :

    Sonstige


    Format :

    Keine Angabe


    Sprache :

    Englisch






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