THz-wave based approaches for the label-free characterization of genetic material are presented. Time-resolved THz spectroscopic analysis of genetic sequences (polynucleotides) demonstrate a clearly distinct complex refractive index in the THz frequency range as a function of the hybridization state (hybridized/denatured) of the analysed DNA sequences. By monitoring THz signals one can thus infer the binding state of oligo- and polynucleotides, enabling the label-free determination of the genetic composition of polynucleotides. A broadband experimental proof-of-principle in a free-space configuration, as well as a first demonstration of a high-sensitivity integrated approach reaching femtomol detection levels and single base mutation detection capabilities, are presented.
THz technology for label-free genetic diagnostics
The 15th Annual Meeting of the IEEE Lasers and Electro-Optics Society ; 1 ; 345-346 vol.1
2002-01-01
160959 byte
Aufsatz (Konferenz)
Elektronische Ressource
Englisch
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