THz-wave based approaches for the label-free characterization of genetic material are presented. Time-resolved THz spectroscopic analysis of genetic sequences (polynucleotides) demonstrate a clearly distinct complex refractive index in the THz frequency range as a function of the hybridization state (hybridized/denatured) of the analysed DNA sequences. By monitoring THz signals one can thus infer the binding state of oligo- and polynucleotides, enabling the label-free determination of the genetic composition of polynucleotides. A broadband experimental proof-of-principle in a free-space configuration, as well as a first demonstration of a high-sensitivity integrated approach reaching femtomol detection levels and single base mutation detection capabilities, are presented.


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    Titel :

    THz technology for label-free genetic diagnostics


    Beteiligte:
    Nagel, M. (Autor:in) / Richter, F. (Autor:in) / Brucherseifer, M. (Autor:in) / Bolivar, P.H. (Autor:in) / Kurz, H. (Autor:in) / Bosserhoff, A. (Autor:in) / Buttner, R. (Autor:in)


    Erscheinungsdatum :

    2002-01-01


    Format / Umfang :

    160959 byte





    Medientyp :

    Aufsatz (Konferenz)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch



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