The present invention provides agents comprising or consisting of a binding moiety with specificity for interleukin-1 receptor accessory protein (IL1RAP) for use in inducing cell death and/or inhibiting the growth and/or proliferation of pathological stem cells and/or progenitor cells associated with a neoplastic hematologic disorder, wherein the cells express IL1RAP. A related aspect of the invention provides agents comprising or consisting of a binding moiety with specificity for interleukin-1 receptor accessory protein (IL1RAP) for use in detecting pathological stem cells and/or progenitor cells associated with a neoplastic hematologic disorder, wherein the cells express IL1RAP. Further provided are pharmacological compositions comprising the agents of the invention and methods of using the same.


    Zugriff

    Download


    Exportieren, teilen und zitieren



    Titel :

    NOVEL AGENTS AND USES THEREOF


    Beteiligte:
    FIORETOS THOAS (Autor:in) / JÄRÅS MARCUS (Autor:in)

    Erscheinungsdatum :

    11.10.2018


    Medientyp :

    Patent


    Format :

    Elektronische Ressource


    Sprache :

    Englisch


    Klassifikation :

    IPC:    G08G Anlagen zur Steuerung, Regelung oder Überwachung des Verkehrs , TRAFFIC CONTROL SYSTEMS / G01C Messen von Entfernungen, Höhen, Neigungen oder Richtungen , MEASURING DISTANCES, LEVELS OR BEARINGS / G06Q Datenverarbeitungssysteme oder -verfahren, besonders angepasst an verwaltungstechnische, geschäftliche, finanzielle oder betriebswirtschaftliche Zwecke, sowie an geschäftsbezogene Überwachungs- oder Voraussagezwecke , DATA PROCESSING SYSTEMS OR METHODS, SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL, SUPERVISORY OR FORECASTING PURPOSES / H04W WIRELESS COMMUNICATION NETWORKS , Drahtlose Kommunikationsnetze



    Novel Block Copolymers and Uses Thereof

    MUYLDERMANS XAVIER DANIEL / STOL MARIANNE / DUPONT MARTINE et al. | Europäisches Patentamt | 2020

    Freier Zugriff

    Highly stretchable adhesive silicone compositions and uses thereof as sealing/bonding agents

    THIRIA REMI / PRICE BRIAN / CARPEN CHRIS et al. | Europäisches Patentamt | 2024

    Freier Zugriff

    HIGHLY STRETCHABLE ADHESIVE SILICONE COMPOSITIONS AND USES THEREOF AS SEALING/BONDING AGENTS

    THIRIA REMI / PRICE BRIAN / CARPEN CHRIS et al. | Europäisches Patentamt | 2021

    Freier Zugriff

    Block copolymers and uses thereof

    MUYLDERMANS XAVIER D D J / STOL MARIANNE / DUPONT MARTINE et al. | Europäisches Patentamt | 2022

    Freier Zugriff

    MODIFIED RESINS AND USES THEREOF

    ARIGO MARK / CARVAGNO TERRI ROXANNE / DE HULLU JACOBUS GILLIS et al. | Europäisches Patentamt | 2022

    Freier Zugriff