The present invention provides, among other things, compositions and methods of formulating nucleic acid-containing nanoparticles comprising no more than three distinct lipids components, one distinct lipid component being a sterol-based cationic lipid. In some embodiments, the present invention provides compositions and methods in which the lipid nanoparticles further comprise helper lipids and PEG-modified lipids. The resulting formulation comprises a high encapsulation percentage for nucleic acids. See Fig. 1. WO 2018/089790 PCT/US2017/061100 c~ll \~. .......~ ~x ,Q 00*% ~ \~~NOV ..... ..... ..... ..... .... MR ft", ~ \~U M .. ..... .... 'M4 ::, , U %U k. .41#~ \k\~ ~ K~ -k~\U\o 'U~Ad PN -~A-' :,\I$$
Trailer connector
2024-02-29
Patent
Elektronische Ressource
Englisch
IPC: | G01R Messen elektrischer Größen , MEASURING ELECTRIC VARIABLES / B60D Fahrzeugverbindungen , VEHICLE CONNECTIONS / B60Q ARRANGEMENT OF SIGNALLING OR LIGHTING DEVICES, THE MOUNTING OR SUPPORTING THEREOF OR CIRCUITS THEREFOR, FOR VEHICLES IN GENERAL , Anordnung von Signal- oder Beleuchtungsvorrichtungen, deren Einbau oder Halterung oder deren Schaltkreise bei Fahrzeugen allgemein / G07C TIME OR ATTENDANCE REGISTERS , Zeit- oder Anwesenheitskontrollgeräte |