AbstractWe have investigated the effect of microgravity during spaceflight on body-wall muscle fiber size and muscle proteins in the paramyosin mutant of Caenorhabditis elegans. Both mutant and wild-type strains were subjected to 10 days of microgravity during spaceflight and compared to ground control groups. No significant change in muscle fiber size or quantity of the protein was observed in wild-type worms; where as atrophy of body-wall muscle and an increase in thick filament proteins were observed in the paramyosin mutant unc-15(e73) animals after spaceflight. We conclude that the mutant with abnormal muscle responded to microgravity by increasing the total amount of muscle protein in order to compensate for the loss of muscle function.


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    Titel :

    Spaceflight results in increase of thick filament but not thin filament proteins in the paramyosin mutant of Caenorhabditis elegans


    Beteiligte:
    Adachi, R. (Autor:in) / Takaya, T. (Autor:in) / Kuriyama, K. (Autor:in) / Higashibata, A. (Autor:in) / Ishioka, N. (Autor:in) / Kagawa, H. (Autor:in)

    Erschienen in:

    Advances in Space Research ; 41 , 5 ; 816-823


    Erscheinungsdatum :

    2007-10-10


    Format / Umfang :

    8 pages




    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch





    Genomic response of the nematode Caenorhabditis elegans to spaceflight

    Selch, Florian / Higashibata, Akira / Imamizo-Sato, Mari et al. | Elsevier | 2007



    Thin-filament velocimetry

    GOSS, L. / GORD, J. / TRUMP, D. et al. | AIAA | 1993


    Filament

    HIRAKAMI DAISUKE / OKONOGI MAKOTO | Europäisches Patentamt | 2018

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