AbstractThe organism is exposed to diverse orthostatic stimuli, which can induce several acute and chronic adaptive responses. In this study, we investigated hemodynamic responses elicited by short-term and intermediate-term various orthostatic stimuli, using normotensive and hypertensive rat models. Arterial blood pressure and heart rate were measured by telemetry. Hypertension was induced by NO-synthase blockade. Effect of orthostatic and inverse-orthostatic body positions were examined in head-up (HUT) or head-down tilt (HDT), either for 5min duration repeated 3 times each with a 5-min pause “”, or as sustained tilting for 120min “”. Data are given as . In normotensives, horizontal control blood pressure was and heart rate was . HUT changed blood pressure by . HDT resulted in augmented blood pressure increase by . In NO-deprived hypertension, horizontal control hemodynamic parameters were and , respectively. HUT and HDT changed blood pressure further by and by , respectively. Heart rate changed only slightly or non-specifically. These data demonstrate that both normotensive and hypertensive conscious rats restricted from longitudinal locomotion respond to sustained orthostasis or inverse-orthostasis related gravitational stimuli with moderate or augmented hypertension, respectively.
Both sustained orthostasis and inverse-orthostasis may elicit hypertension in conscious rat
Acta Astronautica ; 60 , 4-7 ; 415-419
2006-01-01
5 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
Both sustained orthostasis and inverse-orthostasis may elicit hypertension in conscious rat
Online Contents | 2007
|Both sustained orthostasis and inverse-orthostasis may elicit hypertension in conscious rat
British Library Conference Proceedings | 2007
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