Abstract Bone loss induced by microgravity during space flight is one of the most deleterious factors on astronaut’s health and is mainly attributed to an unbalance in the process of bone remodeling. Studies from the space microgravity have demonstrated that the disruption of bone remodeling is associated with the changes of four main functional bone cells, including osteoblast, osteoclast, osteocyte, and mesenchymal stem cells. For the limited availability, expensive costs and confined experiment conditions for conducting space microgravity studies, the mechanism of bone cells response and adaptation to microgravity is still unclear. Therefore, some ground-based simulated microgravity methods have been developed to investigate the bioeffects of microgravity and the mechanisms. Here, based on our studies and others, we review how bone cells (osteoblasts, osteoclasts, osteocytes and mesenchymal stem cells) respond and adapt to simulated microgravity.
Highlights Some popular ground-based simulated microgravity (SM) methods are introduced. The physiological effects of SM on bone cells are reviewed. The possible mechanisms of bone cells responding and adapting to SM are analyzed. We propose the possible research directions and focus in the future.
Response and adaptation of bone cells to simulated microgravity
Acta Astronautica ; 104 , 1 ; 396-408
2014-05-10
13 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
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