AbstractPharmacological norepinephrine transporter (NET) inhibition improves orthostatic tolerance on a tilt table while increasing heart rate. We tested the cardiovascular response to NET inhibition during a graded human centrifuge run in seven healthy men. g-Load was increased in 0.5g steps with 3g maximal g-load. On two separate days, patients were tested after selective NET inhibition with reboxetine or with placebo in a double-blind, randomized, crossover fashion. Resting diastolic blood pressure increased moderately with NET inhibition. Resting heart rate was profoundly increased by NET inhibition. NET inhibition augmented the heart rate response while attenuating the increase in blood pressure during hypergravitation. NET inhibition could be tested for its potential to improve cardiovascular g-tolerance.


    Zugriff

    Zugriff prüfen

    Verfügbarkeit in meiner Bibliothek prüfen

    Bestellung bei Subito €


    Exportieren, teilen und zitieren



    Titel :

    Norepinephrine transporter function and tolerance to hypergravitational stress: A pilot study


    Beteiligte:
    Schroeder, Christoph (Autor:in) / Strempel, Sebastian (Autor:in) / Boese, Andrea (Autor:in) / Hemmersbach, Ruth (Autor:in) / Tank, Jens (Autor:in) / Luft, Friedrich C (Autor:in) / Jordan, Jens (Autor:in)

    Erschienen in:

    Acta Astronautica ; 63 , 7-10 ; 740-744


    Erscheinungsdatum :

    2007-11-18


    Format / Umfang :

    5 pages




    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch






    Norepinephrine transporter function and tolerance to hypergravitational stress: A pilot study

    Schroeder, C. / Strempel, S. / Boese, A. et al. | British Library Conference Proceedings | 2008


    Centrifuge study of pilot tolerance to acceleration on pilot performance

    Creer, B. Y. / Smedal, H. A. / Wingrove, R. C. | NTRS | 1960