Highlights We reviewed the evidence relating the use of analgesics with RTCs in senior drivers. Only nine studies of medium and high quality fulfilled the inclusion criteria. Evidence was weak in terms of number of studies, control of confounders, and consistency of results. The explorative meta-analysis on opioids showed a marginal positive effect. This can be attributed to poor adjustment of key confounders (e.g. concomitant illnesses, use of alcohol and other psychoactive medications).

    Abstract Aim To assess the epidemiological evidence associating the use of analgesics with the occurrence of road traffic crashes in senior drivers including a meta-analysis with specific focus on opioids. Methods Systematic literature review of articles published between 1991 and 2012 retrieved from major databases using relevant key words. Eligible articles were fully reviewed and the main characteristics and results summarized. The methodological quality was assessed using the Newcastle-Ottawa Scale. Heterogeneity tests and forest and funnel plots were used as part of the meta-analysis on opioids. Results From the potentially eligible articles, nine were selected (4 case–control, 1 case-crossover, and 4 cohort studies) of which four were of medium and five of high quality; seven investigated opioids and four non-steroidal anti-inflammatory drugs. Crash involvement (n =7) rather than responsibility (n =2) was investigated. Age and sex were the most common covariates adjusted for. Both opioids and non-steroidal anti-inflammatory drugs showed mixed results including differences across estimates between and within studies. A marginal positive effect was observed in the pooled analyses on opioids (n =6, OR 1.20; 95% CI 1.08–1.32). Conclusions The evidence is unconvincing in terms of number of studies, control of major confounders, and consistency of the results. The effect seen for opioids can be attributed to the lack of adjustment of key confounders such as concomitant illness or the consumption of alcohol or other psychoactive medications. There is a need for more efficient designs like larger population-based retrospective cohorts and nested case–control or case-crossover studies based on registers of high quality allowing adjustment for these factors and for the selection of unequivocal outcomes (e.g. drivers’ responsibility) to produce more persuasive empirical evidence.


    Zugriff

    Zugriff prüfen

    Verfügbarkeit in meiner Bibliothek prüfen

    Bestellung bei Subito €


    Exportieren, teilen und zitieren



    Titel :

    Analgesics and road traffic crashes in senior drivers: An epidemiological review and explorative meta-analysis on opioids


    Beteiligte:

    Erschienen in:

    Erscheinungsdatum :

    2013-04-10


    Format / Umfang :

    8 pages




    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch





    Older drivers’ road traffic crashes in the UK

    Clarke, David D. | Online Contents | 2010


    Older drivers’ road traffic crashes in the UK

    Clarke, David D. / Ward, Patrick / Bartle, Craig et al. | Elsevier | 2009


    Use of prescription opioids and motor vehicle crashes: A meta analysis

    Chihuri, Stanford / Li, Guohua | Elsevier | 2017


    Influence of occupational risk factors for road traffic crashes among professional drivers: systematic review

    Jakobsen, Markus D. / Glies Vincents Seeberg, Karina / Møller, Mette et al. | Taylor & Francis Verlag | 2023

    Freier Zugriff