Abstract Fifteen ewes were assigned as they came into estrus to one of three randomized treatment groups: 1. Sham IUD + Vehicle, 2. IUD + Vehicle or 3. IUD + PGE1 in vehicle. An IUD was inserted adjacent to the luteal-bearing ovary on day 3 postestrus. Prostaglandin E1 (500 μg) in vehicle (Na2CO3) or vehicle was given intrauterine through an indwelling uterine cannula every four hours from day 3 postestrus until ewes returned to estrus. Precocious estrus was induced in both the sham IUD groups receiving vehicle. Prostaglandin E1 prevented an IUD-induced premature luteolysis based on daily concentrations of progesterone in peripheral blood and the interestrous interval. It is concluded that an IUD-induced premature luteolysis is not necessarily via physical distention by the IUD. It is also concluded that chronic intrauterine infusions of PGE1 can prevent an IUD-induced premature luteolysis.


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    Titel :

    Inhibition of an IUD-induced precocious luteolysis by prostaglandin E1 (PGE1) in sheep


    Beteiligte:
    Weems, C. (Autor:in) / Huie, M. (Autor:in) / Magness, R. (Autor:in) / Hoyer, G. (Autor:in) / Whysong, G. (Autor:in)

    Erschienen in:

    Prostaglandins ; 30 , 4 ; 573-580


    Erscheinungsdatum :

    1985-07-15


    Format / Umfang :

    8 pages




    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch




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