Abstract The present state of our knowledge of the OH radical-induced strand break (sb) formation in presence and absence of oxygen in aqueous solution is reviewed for poly(U), poly(C), poly(A) and single- and double-stranded DNA as substrates. It was shown earlier that a single OH radical can induce a double-strand break in DNA. As a key step in the mechanism an interstrand radical transfer is postulated. The OH radical reaction is part of the indirect effect of γ-irradiation. In addition recent results are presented concerning sb formation by the direct effect of high-energy irradiation using laser-induced photoionization for the formation of radical cations.


    Zugriff

    Zugriff prüfen

    Verfügbarkeit in meiner Bibliothek prüfen

    Bestellung bei Subito €


    Exportieren, teilen und zitieren



    Titel :

    Mechanism of radiation-induced strand break formation in DNA and polynucleotides


    Beteiligte:

    Erschienen in:

    Erscheinungsdatum :

    01.01.1987


    Format / Umfang :

    8 pages




    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch




    DNA Double Strand Break Repair and Its Control by Nucleosome Remodeling

    Karl, L.A. / Peritore, M. / Galanti, L. et al. | Deutsches Zentrum für Luft- und Raumfahrt (DLR) | 2022

    Freier Zugriff

    TWO-LAYER MULTI-STRAND CABLE HAVING AN IMPROVED SURFACE ENERGY-TO-BREAK

    CHEVALLEY MARIANNA / LAURENT STEPHANE / BARBAT ROMAIN et al. | Europäisches Patentamt | 2022

    Freier Zugriff

    Theoretical consideration of the chemical pathways for radiation-induced strand breaks

    Chatterjee, A. / Koehl, P. / Magee, J.L. | Elsevier | 1987