In vertebrate embryos, anterior tissues are generated early, followed by the other axial structures that emerge sequentially from a posterior growth zone. The genetic network driving posterior axial elongation in mice, and its disturbance in mutants with posterior truncation, is not yet fully understood. Here, we show that the combined expression of Cdx2 and T Brachyury is essential to establish the core signature of posterior axial progenitors. Cdx2 and T Brachyury are required for extension of a similar trunk portion of the axis. Simultaneous loss of function of these two genes disrupts axial elongation to a much greater extent than each single mutation alone. We identify and validate common targets for Cdx2 and T Brachyury in vivo, including Wnt and Fgf pathway components active in the axial progenitor niche. Our data demonstrate that integration of the Cdx/Hox and T Brachyury transcriptional networks controls differential axial growth during vertebrate trunk elongation.


    Zugriff

    Download


    Exportieren, teilen und zitieren



    Titel :

    Cdx and T Brachyury Co-activate Growth Signaling in the Embryonic Axial Progenitor Niche


    Beteiligte:

    Erscheinungsdatum :

    2016-12-20


    Anmerkungen:

    Amin , S , Neijts , R , Simmini , S , van Rooijen , C , Tan , S C , Kester , L , van Oudenaarden , A , Creyghton , M P & Deschamps , J 2016 , ' Cdx and T Brachyury Co-activate Growth Signaling in the Embryonic Axial Progenitor Niche ' , Cell Reports , vol. 17 , no. 12 , pp. 3165-3177 . https://doi.org/10.1016/j.celrep.2016.11.069



    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch


    Klassifikation :

    DDC:    629




    The Glandular Stem/Progenitor Cell Niche in Airway Development and Repair

    Liu, X. / Engelhardt, J.F. | British Library Conference Proceedings | 2008


    Reconstructing the Differentiation Niche of Embryonic Stem Cells Using Biomaterials

    Dickinson, L. E. / Kusuma, S. / Gerecht, S. | British Library Online Contents | 2011



    Niche within a niche

    British Library Online Contents | 2004