Ripples are brief high-frequency electrographic events with important roles in episodic memory. However, the in vivo circuit mechanisms coordinating ripple-related activity among local and distant neuronal ensembles are not well understood. Here, we define key characteristics of a long-distance projecting GABAergic cell group in the mouse hippocampus that selectively exhibits high-frequency firing during ripples while staying largely silent during theta-associated states when most other GABAergic cells are active. The high ripple-associated firing commenced before ripple onset and reached its maximum before ripple peak, with the signature theta-OFF, ripple-ON firing pattern being preserved across awake and sleep states. Controlled by septal GABAergic, cholinergic, and CA3 glutamatergic inputs, these ripple-selective cells innervate parvalbumin and cholecystokinin-expressing local interneurons while also targeting a variety of extra-hippocampal regions. These results demonstrate the existence of a hippocampal GABAergic circuit element that is uniquely positioned to coordinate ripple-related neuronal dynamics across neuronal assemblies.
Ripple-selective GABAergic projection cells in the hippocampus
2022-06-01
Szabo , G G , Farrell , J S , Dudok , B , Hou , W H , Ortiz , A L , Varga , C , Moolchand , P , Gulsever , C I , Gschwind , T , Dimidschstein , J , Capogna , M & Soltesz , I 2022 , ' Ripple-selective GABAergic projection cells in the hippocampus ' , Neuron , vol. 110 , no. 12 , pp. 1959-1977.e9 . https://doi.org/10.1016/j.neuron.2022.04.002
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
brain state , disinhibition , GABA , hippocampus , inhibition , medial septum , muscarinic , sharp-wave ripple , sleep
DDC: | 629 |
Tema Archiv | 2014
|IuD Bahn | 2010
|AIAA | 1981
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