Purpose.: To investigate microrobots as an assistive tool for minimally invasive intraocular surgery and to demonstrate mobility and controllability inside the living rabbit eye. / Methods.: A system for wireless magnetic control of untethered microrobots was developed. Mobility and controllability of a microrobot are examined in different media, specifically vitreous, balanced salt solution (BSS), and silicone oil. This is demonstrated through ex vivo and in vivo animal experiments. / Results.: The developed electromagnetic system enables precise control of magnetic microrobots over a workspace that covers the posterior eye segment. The system allows for rotation and translation of the microrobot in different media (vitreous, BSS, silicone oil) inside the eye. / Conclusions.: Intravitreal introduction of untethered mobile microrobots can enable sutureless and precise ophthalmic procedures. Ex vivo and in vivo experiments demonstrate that microrobots can be manipulated inside the eye. Potential applications are targeted drug delivery for maculopathies such as AMD, intravenous deployment of anticoagulation agents for retinal vein occlusion (RVO), and mechanical applications, such as manipulation of epiretinal membrane peeling (ERM). The technology has the potential to reduce the invasiveness of ophthalmic surgery and assist in the treatment of a variety of ophthalmic diseases.


    Zugriff

    Download


    Exportieren, teilen und zitieren



    Titel :

    Mobility Experiments With Microrobots for Minimally Invasive Intraocular Surgery


    Beteiligte:
    Ullrich, F (Autor:in) / Bergeles, C (Autor:in) / Pokki, J (Autor:in) / Ergeneman, O (Autor:in) / Erni, S (Autor:in) / Chatzipirpiridis, G (Autor:in) / Pané, S (Autor:in) / Framme, C (Autor:in) / Nelson, BJ (Autor:in)

    Erscheinungsdatum :

    01.04.2013


    Anmerkungen:

    Investigative Opthalmology & Visual Science , 54 (4) pp. 2853-2863. (2013)


    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch


    Klassifikation :

    DDC:    629



    Minimally invasive surgery

    Online Contents | 1994


    In vivo accessories for minimally invasive surgery

    JULIAN CHRISTOPHER A / WALLACE DANIEL T / MOLL FREDERIC H et al. | Europäisches Patentamt | 2016

    Freier Zugriff

    Robot Assisted Object Manipulation for Minimally Invasive Surgery

    D'Ettorre, Claudia | BASE | 2022

    Freier Zugriff

    Hyper redundant active endoscope for minimally invasive surgery

    Ikuta, K. / Nokata, M. / Aritomi, S. | British Library Online Contents | 1998


    Laser Diffusing Devices with New Applications in Minimally Invasive Surgery

    IEEE; Lasers and Electro-Optics Society | British Library Conference Proceedings | 1998