Brain activation mapping using functional MRI (fMRI) based on blood oxygenation level-dependent (BOLD) contrast has been conventionally focused on probing gray matter, the BOLD contrast in white matter having been generally disregarded. Recent results have provided evidence of the functional significance of the white matter BOLD signal, showing at the same time that its correlation structure is highly anisotropic, and related to the diffusion tensor in shape and orientation. This evidence suggests that conventional isotropic Gaussian filters are inadequate for denoising white matter fMRI data, since they are incapable of adapting to the complex anisotropic domain of white matter axonal connections. In this paper we explore a graph-based description of the white matter developed from diffusion MRI data, which is capable of encoding the anisotropy of the domain. Based on this representation we design localized spatial filters that adapt to white matter structure by leveraging graph signal processing principles. The performance of the proposed filtering technique is evaluated on semi-synthetic data, where it shows potential for greater sensitivity and specificity in white matter activation mapping, compared to isotropic filtering. ; Funding agencies: Swedish Research CouncilSwedish Research Council [2018-06689, 2017-04889]; Center for Industrial Information Technology (CENIIT) at Linkoping University; Wallenberg AI, Autonomous Systems and Software Program (WASP) - Knut and Alice Wallenberg Foundation


    Zugriff

    Download


    Exportieren, teilen und zitieren



    Titel :

    Improved Functional MRI Activation Mapping in White Matter Through Diffusion-Adapted Spatial Filtering


    Beteiligte:
    Abramian, David (Autor:in) / Larsson, Martin (Autor:in) / Eklund, Anders (Autor:in) / Behjat, Hamid (Autor:in)

    Erscheinungsdatum :

    2020-01-01



    Medientyp :

    Aufsatz (Konferenz)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch



    Klassifikation :

    DDC:    629



    Adjugate Diffusion Tensors for Geodesic Tractography in White Matter

    Fuster, A. | British Library Online Contents | 2016


    Adapted torque motorisation system for deployable spatial structures

    BAUDASSE YANNICK / VEZAIN STÉPHANE | Europäisches Patentamt | 2016

    Freier Zugriff

    Coherence-Enhancing Diffusion Filtering

    Weickert, J. | British Library Online Contents | 1999


    IMPROVED FILTERING PULLEY

    CARICCIA GIANLUCA / GUALA ANDREA / LICATA FEDERICO DOMENICO et al. | Europäisches Patentamt | 2023

    Freier Zugriff

    IMPROVED FILTERING PULLEY

    CARICCIA GIANLUCA / GUALA ANDREA / LICATA FEDERICO DOMENICO et al. | Europäisches Patentamt | 2021

    Freier Zugriff