Objectives: This study aims to investigate the effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model. Materials and methods: Between May 2006 and July 2006, 60 female Wistar Albino rats aged three months were randomly allocated to three groups: sham operated receiving no treatment (Shm); ovariectomized-alendronate receiving 1 mg/kg/day alendronate sodium (Ovx-A), and ovariectomized-vehicle receiving 1 mL/kg/day physiological saline (Ovx-PS). Both Ovx groups received treatment through gastric gavage for 56 days. Results: Densitometric measurements showed that bone mineral density decreased in the Ovx-PS and increased in Ovx-A groups (p<0.05). Biomechanical measurements showed a decrease in the breaking force in the Ovx-PS group and an increase in the Ovx-A group (p<0.05). Histomorphometric measurements showed that the Shm group had normal trabecular structure, while the Ovx-PS group had a less well-formed trabecular structure with a loss in the trabecular number and thickness and a corresponding increase in the trabecular spacing (p<0.05). In the Ovx-A group, there was an improvement in the trabecular structure with an increase in the trabecular number and thickness and a loss in the trabecular space (p<0.05). Conclusion: Our study results suggest that alendronate sodium is a valuable treatment agent for osteoporosis in postmenopausal women.
The effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model
01.01.2017
000422785900009
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
Normal ''osteoporotic'' bone loss
NTRS | 1966
|Magnetic Resonance Microscopy of Osteoporotic Bone
British Library Conference Proceedings | 2000
|Magnetic resonance microscopy of osteoporotic bone
American Institute of Physics | 2000
|Comprehensive biomechanical analysis of microcosmic trabecular structure of cancellous bone
British Library Online Contents | 2008
|