Vascular targeted photodynamic therapy (V-PDT) has shown satisfied efficiency in treating vascular-related diseases including age-related macular degeneration, port-wine stains (PWS), and prostate cancer. Its efficacy is a complex function of photosensitizer (PS) uptake, oxygen concentration, PS-activating light dose and tissue optical properties. In order to non -invasively monitor PS distribution and photobleaching, blood vessel contraction and blood flow velocity for V-PDT response, a multimode optical imaging (MOI) system was developed to capture PS fluorescence image, narrow band image and laser speckle image, respectively. V-PDT in vivo studies were performed, which suggests that our MOI system is capable of monitoring dynamic response during V-PDT treatment.


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    Titel :

    Monitoring vascular targeted PDT response with multimode optical imaging


    Beteiligte:
    Shen, Yi (Autor:in) / Liang, Fuqiang (Autor:in) / Niu, Yanhui (Autor:in) / Lin, Huiyun (Autor:in) / Gu, Ying (Autor:in) / Wilson, Brian C. (Autor:in) / Li, Buhong (Autor:in)

    Kongress:

    Biophotonics and Immune Responses XIV ; 2019 ; San Francisco,California,United States


    Erschienen in:

    Proc. SPIE ; 10879


    Erscheinungsdatum :

    2019-03-07





    Medientyp :

    Aufsatz (Konferenz)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch



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