Vascular targeted photodynamic therapy (V-PDT) has shown satisfied efficiency in treating vascular-related diseases including age-related macular degeneration, port-wine stains (PWS), and prostate cancer. Its efficacy is a complex function of photosensitizer (PS) uptake, oxygen concentration, PS-activating light dose and tissue optical properties. In order to non -invasively monitor PS distribution and photobleaching, blood vessel contraction and blood flow velocity for V-PDT response, a multimode optical imaging (MOI) system was developed to capture PS fluorescence image, narrow band image and laser speckle image, respectively. V-PDT in vivo studies were performed, which suggests that our MOI system is capable of monitoring dynamic response during V-PDT treatment.
Monitoring vascular targeted PDT response with multimode optical imaging
Biophotonics and Immune Responses XIV ; 2019 ; San Francisco,California,United States
Proc. SPIE ; 10879
2019-03-07
Aufsatz (Konferenz)
Elektronische Ressource
Englisch
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