Abstract Domain structures of class I and class II MHC products were analyzed from a viewpoint of amino acid and nucleotide sequence homologies. Alignment statistics revealed that class I (transplantation) antigen H chains consist of four mutually homologous domains, and that class II (HLA-DR) antigen β and α chains are both composed of three mutually homologous ones. The N-terminal three and two domains of class I and class II (both β and α) gene products, respectively, all of which being ∼90 residues long, were concluded to be homologous to $ β_{2} $-microglobulin ($ β_{2} $M). The membraneembedded C-terminal shorter domains of these MHC products were also found to be homologous to one another and to the third domain of class I H chains. Class I H chains were found to be more closely related to class II α chains than to class II β chains. Based on these findings, an exon duplication history from a common ancestral gene encoding a $ β_{2} $M-like primodial protein of one-domain-length up to the contemporary MHC products was proposed.


    Zugriff

    Zugriff über TIB

    Verfügbarkeit in meiner Bibliothek prüfen

    Bestellung bei Subito €


    Exportieren, teilen und zitieren



    Titel :

    Domain structures and molecular evolution of class I and class II major histocompatibility gene complex (MHC) products deduced from amino acid and nucleotide sequence homologies


    Beteiligte:
    Ohnishi, Koji (Autor:in)

    Erschienen in:

    Erscheinungsdatum :

    1984




    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Print


    Sprache :

    Englisch



    Klassifikation :

    Lokalklassifikation TIB:    535/3908/4290
    BKL:    44.71 Verkehrsmedizin



    "River class" evolution

    Engineering Index Backfile | 1946


    "River class" evolution

    Engineering Index Backfile | 1946


    Lunar structures as deduced from Muong Nong tektites

    O'Keefe, J. A. / Adler, I. | TIBKAT | 1966


    Lunar Structures as Deduced from Muong Nong Tektites

    I. Adler / J. A. Okeefe | NTIS | 1966


    Planar homologies as a basis for grouping and recognition

    Van Gool, L. / Proesmans, M. / Zisserman, A. | British Library Online Contents | 1998