Conclusion The specificity of tRNA aminoacylation as well as the origin of the genetic code are far from being understood at the molecular and evolutionnary level. The “tRNA-tRNA interaction model” could provide a missing link for resolving both problems. The model suggests a direct chemical interaction between the nucleotides in the anticodon, and the amino acid (adenylate) to be transferred to the 3′-terminal adenosine, within the catalytic center (23). The experimental data reviewed here indicate that in many, but not all, systems the anticodon does play a major role during the aminoacylation and that the simultaneous binding of two tRNA molecules for aminoacylation (of only one of them) does not contradict enzymatic and crystallographic data (24).


    Zugriff

    Zugriff über TIB

    Verfügbarkeit in meiner Bibliothek prüfen

    Bestellung bei Subito €


    Exportieren, teilen und zitieren



    Titel :

    Origin of the genetic code and specificity of tRNA aminoacylation. A testable model


    Beteiligte:

    Erschienen in:

    Erscheinungsdatum :

    1984




    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Print


    Sprache :

    Englisch



    Klassifikation :

    Lokalklassifikation TIB:    535/3908/4290
    BKL:    44.71 Verkehrsmedizin




    On the stereoselective aminoacylation of RNA

    Usher, D. A. / Needels, M. C. | NTRS | 1984


    The origin of the genetic code

    Ishigami, Masahiro / Nagano, Kei | Online Contents | 1975


    Modular testable release mechanism

    ERIAN HANY F | Europäisches Patentamt | 2017

    Freier Zugriff

    HARDWARE TESTABLE CLOSE-IN WEAPONS SYSTEM

    Europäisches Patentamt | 2023

    Freier Zugriff