Abstract A new approach to the origin of the genetic code is proposed based on some regularities in the nucleotide distribution pattern of the code. The relative amounts of various amino acids in primitive proteins were possibly different from those in organisms living today. The primordial ratio was supposed to shift to the modern one guided by the action of primitive nucleotides. Each primitive tRNA had a discriminator site and, distinguished from it, an anticodon site. It is also postulated that primordially each amino acid could correspond to a wide variety of codons. During the course of the evolutionary change, a selective mechanism worked among the protobionts so that less frequent nucleotides became associated with more abundant amino acids in the primordial conditions, thus finally leading to the present codon catalogue.


    Zugriff

    Zugriff über TIB

    Verfügbarkeit in meiner Bibliothek prüfen

    Bestellung bei Subito €


    Exportieren, teilen und zitieren



    Titel :

    The origin of the genetic code


    Beteiligte:
    Ishigami, Masahiro (Autor:in) / Nagano, Kei (Autor:in)

    Erschienen in:

    Erscheinungsdatum :

    1975




    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Print


    Sprache :

    Englisch



    Klassifikation :

    Lokalklassifikation TIB:    535/3908/4290
    BKL:    44.71 Verkehrsmedizin



    Genetics and the origin of the genetic code

    Walker, G. W. R. | Online Contents | 1974


    On the possible origin and evolution of the genetic code

    Jukes, Thomas H. | Online Contents | 1974



    Origin of the genetic code: A physical-chemical model of primitive codon assignments

    Nagyvary, Joseph / Fendler, Janos H. | Online Contents | 1974