The effect of microgravity on mammalian system is an important and interesting topic for scientific investigation, since NASA s objective is to send manned flights to planets like Mars and eventual human colonization. The Astronauts will be exposed to microgravity environment for a long duration of time during these flights. Our objective of research is to conduct in vitro studies for the effect of microgravity on mammalian immune system and nervous system. We did our preliminary investigations by exposing mammalian lymphocytes and astrocyte cells to a microgravity simulator cell bioreactor designed by NASA and manufactured at Synthecon, Inc. (USA).Our initial results showed no significant change in cytokine expression in these cells up to a time period of 120 hours exposure. Our future experiments will involve exposure for a longer period of time.


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    Titel :

    Effect of Microgravity on Mammalian Lymphocytes


    Beteiligte:
    Banerjee, H. (Autor:in) / Blackshear, M. (Autor:in) / Mahaffey, K. (Autor:in) / Khan, A. A. (Autor:in) / Delucas, L. (Autor:in)


    Erscheinungsdatum :

    2004-08-01


    Medientyp :

    Aufsatz (Konferenz)


    Format :

    Keine Angabe


    Sprache :

    Englisch


    Schlagwörter :


    Effect of Microgravity on Mammalian Lymphocytes

    Banerjee, H. / Blackshear, M. / Mahaffey, K. et al. | NTRS | 2004


    Mitogen binding, cytoskeleton patterns and motility of T lymphocytes in microgravity

    Cogoli-Greuter, M. / Sciola, L. / Pippia, P. et al. | British Library Online Contents | 1997


    Effect of Simulated Microgravity Conditions on Radiation-Induced Chromosome Aberrations and DNA-Repair in Human Lymphocytes

    Mosesso, Y. / Schuber, M. / Seibt, D. et al. | British Library Online Contents | 1996


    Early transcriptional response of human T-lymphocytes to microgravity conditions during Maser 9 vector flight

    Negri, R. / Constanzo, G. / Galleri, G. et al. | British Library Conference Proceedings | 2003