Atrophy of skeletal muscles is a serious problem in a microgravity environment. It is hypothesized that the unloading of postural muscles, which no longer must resist gravity force, causes an accelerated breakdown of contractile proteins, resulting in reduction in muscle mass and strength. A crustacean model using the land crab, Gecarcinus lateralis, to assess the effects of spaceflight on protein meatabolism is presented. The model is compared to a developmentally-regulated atrophy in which a premolt reduction in muscle mass allows the withdrawal of the large claws at molt. The biochemical mechanisms underlying protein breakdown involves both Ca2(+) -dependent and multicatalytic proteolytic enzymes. Crustacean claw muscle can be used to determine the interactions between shortening and unloading at the molecular level.


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    Titel :

    Crustaceans as a model for microgravity-induced muscle atrophy


    Beteiligte:
    Mykles, D. L. (Autor:in)

    Erschienen in:

    Erscheinungsdatum :

    1996-01-01



    Medientyp :

    Sonstige


    Format :

    Keine Angabe


    Sprache :

    Englisch






    Crustaceans as a Model for Microgravity-Induced Muscle Atrophy

    Mykles, D. L. / Committee on Space Research; Scientific Commission F | British Library Conference Proceedings | 1995


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    Falempin, M. / Mounier, Y. / International Academy of Astronautics et al. | British Library Conference Proceedings | 1998