Evidence from both human and rodent studies has indicated that alterations in immunological parameters occur after space flight. The number of flight experiments has been small, and the full breadth of immunological alterations occurring after space flight remains to be established. Among the major effects on immune responses after space flight that have been reported are: alterations in lymphocyte blastogenesis and natural killer cell activity, alterations in production of cytokines, changes in leukocyte sub-population distribution, and decreases in the ability in the ability of bone marrow cells to respond to colony stimulating factors. Changes have been reported in immunological parameters of both humans and rodents. The significance of these alterations in relation to resistance to infection remains to be established. The current study involved a determination of the effects of flight on Cosmos mission 2044 on leukocyte subset distribution and the sensitivity of bone marrow cells to colony stimulating factor-GM. A parallel study with antiorthostatic suspension was also carried out. The study involved repetition and expansion of studies carried out on Cosmos 1887.


    Zugriff

    Zugriff über TIB

    Verfügbarkeit in meiner Bibliothek prüfen


    Exportieren, teilen und zitieren



    Titel :

    Cosmos-1989 immunology studies


    Beteiligte:

    Erscheinungsdatum :

    1991-10-01


    Medientyp :

    Report


    Format :

    Keine Angabe


    Sprache :

    Englisch




    Cosmos: 1989 immunology studies

    Sonnenfeld, Gerald | NTRS | 1991



    Results of immunological experiments aboard the Cosmos biosatellites and problems in space immunology

    Konstantinova, I. V. / Sonnenfeld, G. / Schaffar, L. et al. | NTRS | 1992


    Hematology and immunology studies

    Stephen L. Kimzey / Craig L. Fischer / Philip C. Johnson et al. | NTRS | 1975


    Cosmos calculations

    Pilkington, J.A. | Engineering Index Backfile | 1963