Two versions of bioreactor vessel provide steady supplies of oxygen and nutrients with little turbulence. Suspends cells in environment needed for sustenance and growth, while inflicting less damage from agitation and bubbling than do propeller-stirred reactors. Gentle environments in new reactors well suited to delicate mammalian cells. One reactor kept human kidney cells alive for as long as 11 days. Cells grow on carrier beads suspended in liquid culture medium that fills cylindrical housing. Rotating vanes - inside vessel but outside filter - gently circulates nutrient medium. Vessel stationary; magnetic clutch drives filter cylinder and vanes. Another reactor creates even less turbulence. Oxygen-permeable tubing wrapped around rod extending along central axis. Small external pump feeds oxygen to tubing through rotary coupling, and oxygen diffuses into liquid medium.


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    Titel :

    Controlled-Turbulence Bioreactors


    Beteiligte:
    Wolf, David A. (Autor:in) / Schwartz, Ray (Autor:in) / Trinh, Tinh (Autor:in)

    Erschienen in:

    Erscheinungsdatum :

    1989-10-01



    Medientyp :

    Sonstige


    Format :

    Keine Angabe


    Sprache :

    Englisch


    Schlagwörter :


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    Turbulence controlled induction

    Dye, A. | Tema Archiv | 1976


    CONTROLLED TURBULENCE SYSTEM

    DALMAS ELARIO / LEATHERS BRETT / SHOENBERGER DOUGLAS | Europäisches Patentamt | 2020

    Freier Zugriff

    Monolithic Continuous-Flow Bioreactors

    Stephanopoulos, Gregory / Kornfield, Julia A. / Voecks, Gerald A. | NTRS | 1993


    Thin film bioreactors in space

    Hughes-Fulford, M. / Scheld, H.W. | Elsevier | 1989