The effects of restaint on immunological parameters was determined in an 18 day ARRT (Adult Rhesus Restraint Test). The monkeys were restrained for 18 days in the Experimental Station for the Orbiting Primate (ESOP), the chair of choice for Space Shuttle experiments. Several immunological parameters were determined using peripheral blood, bone marrow, and lymph node specimens from the monkeys. The parameters included: response of bone marrow cells to GM-CSF (Granulocyte-Macrophage Colony Stimulating Factor), leukocyte subset distribution, and production of IFN-alpha (interferon-alpha) and IFN-gamma (Interferon-gamma). The only parameter changed after 18 days of restraint was the percentage of CDB+ T cells. No other immunological parameters showed changes due to restraint. Handling and changes in housing prior to the restraint period did apparently result in some restraint-independent immunological changes. Handling must be kept to a minimum and the animals allowed time to recover prior to flight. All experiments must be carefully controlled. Restraint does not appear to be a major issue regarding the effects of space flight on immune responses.


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    Titel :

    Movement Limitation and Immune Responses of Phesus Monkeys


    Beteiligte:
    G. Sonnenfeld (Autor:in) / D. S. Morton (Autor:in) / J. P. Swiggett (Autor:in) / A. M. Hakenewerth (Autor:in) / N. A. Fowler (Autor:in)

    Erscheinungsdatum :

    1993


    Format / Umfang :

    16 pages


    Medientyp :

    Report


    Format :

    Keine Angabe


    Sprache :

    Englisch




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    G. Sonnenfeld / D. S. Morton / J. P. Swiggett et al. | NTIS | 1995




    Spaceflight and immune responses of rhesus monkeys

    Sonnenfeld, Gerald / Morton, Darla S. / Swiggett, Jeanene P. et al. | NTRS | 1995