The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro-transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3′-untranslated region (UTR) of an RNA molecule improve stability and translation efficiency.
3′-UTR sequences for stabilization of RNA
2022-11-08
Patent
Elektronische Ressource
Englisch
IPC: | C12N Mikroorganismen oder Enzyme , MICROORGANISMS OR ENZYMES / A47B Tische , TABLES / A47C Stühle , CHAIRS / A47K Sanitäre Ausstattung, soweit nicht anderweitig vorgesehen , SANITARY EQUIPMENT NOT OTHERWISE PROVIDED FOR / B60B VEHICLE WHEELS , Räder für Fahrzeuge / E04H Gebäude oder ähnliche Bauwerke für besondere Zwecke , BUILDINGS OR LIKE STRUCTURES FOR PARTICULAR PURPOSES / F16C SHAFTS , Wellen |
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