A process for the preparation of a bioadhesive laminate comprising a hot-melt extruded reservoir layer and a hot-melt extruded backing layer is provided. The reservoir layer comprises a thermoplastic bioadhesive composition containing an active agent. An active agent-containing thermoplastic bioadhesive hydrophilic composition is hot-melt coextruded with a hydrophobic composition to form at least a bi-layered laminate. The hydrophilic composition and the hydrophobic composition have at least one polymer in common. In addition, the melt flow index of the hydrophobic composition is within 50% of the melt flow index of the hydrophilic composition. As a result, the laminate has a uniform transverse cross-section and/or a uniform longitudinal cross-section throughout a major of the length of the laminate. Moreover, when the laminate is divided into unit doses of approximately the same size, they have a high degree of content uniformity with respect to the active agent(s) present therein.


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    Titel :

    PROCESS FOR THE PREPARATION OF A HOT-MELT EXTRUDED LAMINATE


    Weitere Titelangaben:

    PROCEDE DE PREPARATION D'UN STRATIFIE EXTRUDE A CHAUD


    Beteiligte:
    CROWLEY MICHAEL M (Autor:in) / KEEN JUSTIN M (Autor:in) / KOLENG JOHN J (Autor:in) / ZHANG FENG (Autor:in)

    Erscheinungsdatum :

    2015-04-14


    Medientyp :

    Patent


    Format :

    Elektronische Ressource


    Sprache :

    Englisch


    Klassifikation :

    IPC:    B29C Formen oder Verbinden von Kunststoffen , SHAPING OR JOINING OF PLASTICS / A61K Zubereitungen für medizinische, zahnärztliche oder kosmetische Zwecke , PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES / B61F Untergestelle für Schienenfahrzeuge, z.B. Fahrgestellrahmen, Drehgestelle oder Anordnungen der Radsätze , RAIL VEHICLE SUSPENSIONS, e.g. UNDERFRAMES, BOGIES OR ARRANGEMENTS OF WHEEL AXLES



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