AbstractPrevious studies have shown that radiation exposure, particularly to particles of high energy and charge (HZE particles) such as 56Fe, produces deficits in spatial learning and memory. These adverse behavioral effects are similar to those seen in aged animals. It is possible that these shared effects may be produced by the same mechanism. For example, an increased release of reactive oxygen species, and the subsequent oxidative stress and inflammatory damage caused to the central nervous system, is likely responsible for the deficits seen in aging and following irradiation. Therefore, dietary antioxidants, such as those found in fruits and vegetables, could be used as countermeasures to prevent the behavioral changes seen in these conditions. Both aged and irradiated rats display cognitive impairment in tests of spatial learning and memory such as the Morris water maze and the radial arm maze. These rats have decrements in the ability to build spatial representations of the environment, and they utilize non-spatial strategies to solve tasks. Furthermore, they show a lack of spatial preference, due to a decline in the ability to process or retain place (position of a goal with reference to a “map” provided by the configuration of numerous cues in the environment) information. These declines in spatial memory occur in measures dependent on both reference and working memory, and in the flexibility to reset mental images. These results show that irradiation with 56Fe high-energy particles produces age-like decrements in cognitive behavior that may impair the ability of astronauts, particularly middle-aged ones, to perform critical tasks during long-term space travel beyond the magnetosphere.


    Zugriff

    Zugriff prüfen

    Verfügbarkeit in meiner Bibliothek prüfen

    Bestellung bei Subito €


    Exportieren, teilen und zitieren



    Titel :

    Exposure to 56Fe irradiation accelerates normal brain aging and produces deficits in spatial learning and memory


    Beteiligte:

    Erschienen in:

    Advances in Space Research ; 39 , 6 ; 1087-1092


    Erscheinungsdatum :

    2006-11-12


    Format / Umfang :

    6 pages




    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch





    Cognitive deficits induced by 56Fe radiation exposure

    Shukitt-Hale, B. / Casadesus, G. / Cantuti-Castelvetri, I. et al. | Elsevier | 2002


    Cognitive deficits induced by 56Fe radiation exposure

    Shukitt-Hale, B. | Online Contents | 2003


    Dietary modulation of the effects of exposure to 56Fe particles

    Rabin, B.M. / Joseph, J.A. / Shukitt-Hale, B. et al. | Elsevier | 2007