AbstractThe brain of the Kun-Ming strain mice were irradiated with 0.05Gy of 12C6+ ion or 60Co γ-ray as the pre-exposure dose, and were then irradiated with 2Gy of 12C6+ ion or 60Co γ-ray as challenging irradiation dose at 4h after per-exposure. Body weight and serum growth hormone (GH) concentration were measured at 35th day after irradiation. The results showed that irradiation of mouse brain with 2Gy of 12C6+ ion or 60Co γ-ray significantly diminished mouse body weight and level of serum GH. The relative biological effectiveness values of a 2Gy dose of 12C6+ ion calculated with respect to 60Co γ-ray were 1.47 and 1.34 for body weight and serum GH concentration, respectively. Pre-exposure with a low-dose (0.05Gy) of 12C6+ ion or 60Co γ-ray significantly alleviated reductions of mouse body weight and level of serum GH induced by a subsequent high-dose (2Gy) irradiation. The data suggested that low-dose ionizing irradiation can induce adaptive hormetic responses to the harmful effects of pituitary by subsequent high-dose exposure.


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    Titel :

    Adaptive hormetic response of pre-exposure of mouse brain with low-dose 12C6+ ion or 60Co γ-ray on growth hormone (GH) and body weight induced by subsequent high-dose irradiation


    Beteiligte:
    Zhang, Hong (Autor:in) / Xie, Yi (Autor:in) / Zhou, Qingming (Autor:in) / Liu, Bing (Autor:in) / Li, Wenjian (Autor:in) / Li, Xiaoda (Autor:in) / Duan, Xin (Autor:in) / Yuan, Zhigang (Autor:in) / Zhou, Guangming (Autor:in) / Min, Fengling (Autor:in)

    Erschienen in:

    Advances in Space Research ; 38 , 6 ; 1148-1151


    Erscheinungsdatum :

    2006-03-28


    Format / Umfang :

    4 pages




    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch