AbstractWith space missions of expanding durations, astronauts will be exposed to increasing amounts of high linear energy transfer heavy ion radiation. One of the potential risks for humans traveling beyond the Earth’s magnetic fields is radiation induced central nervous system damage because these post-mitotic cells cannot replenish themselves. Although neuronal progenitor cells offer hope to replace dead or damaged neurons, very little is known about the effects of heavy ion radiation on them. Thus, we utilized a cloned line of human neuronal progenitor (NT2) cells as a model and measured their responses to irradiation with 1GeV/nucleon 56Fe26+ ions. Numerous parameters of radiation toxicity, such as cell detachment, necrosis and apoptosis were induced in both time and dose dependent manners. The highest effect in each case was detected 48h post-irradiation, and a dose as small as 10cGy resulted in statistically significant increases in all three of these measurements. In addition, cell cycle analysis revealed that NT2 cells underwent a G2 phase specific cell cycle delay within 6h after irradiation, and that this response was transient. These results emphasize the importance of determining how human neuronal progenitor cells respond to high linear energy transfer heavy ion radiation.


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    Titel :

    Cytotoxic and cell cycle effects in human neuronal progenitor cells exposed to 1GeV/n Fe ions


    Beteiligte:

    Erschienen in:

    Advances in Space Research ; 39 , 6 ; 1004-1010


    Erscheinungsdatum :

    2006-12-06


    Format / Umfang :

    7 pages




    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch





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