Abstract To understand the mechanisms of accelerated heavy ions on biological matter, the responses of spores of B. subtilis to this structured high LET radiation was investigated applying two different approaches. 1) By the use of the Biostack concept, the inactivation probability as a function of radial distance to single particles' trajectory (i.e. impact parameter) was determined in space experiments as well as at accelerators using low fluences of heavy ions. It was found that spores can survive even a central hit and that the effective range of inactivation extends far beyond impact parameters where inactivation by δ-ray dose would be effective. Concerning the space exeriment, the inactivation cross section exceeds those from comparable accelerator experiments by roughly a factor of 20. 2) From fluence effect curves, cross sections for inactivation and mutation induction, and the efficiency of repair processes were determined. They are influenced by the ions characteristics in a complex manner. According to dependence on LET, at least 3 LET ranges can be differentiated: A low LET range (app. < 200 keV/μm), where cross sections for inactivation and mutation induction follow a common curve for different ions and where repair processes are effective; an intermediate LET range of the so-called saturation cross section with negligible mutagenic and repair efficiency; and a high LET range (> 1000 keV/μm) where the biological endpoints are majorly dependent on atomic mass and energy of the ion under consideration.


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    Titel :

    Cell inactivation, repair and mutation induction in bacteria after heavy ion exposure: Results from experiments at accelerators and in space


    Beteiligte:
    Horneck, G. (Autor:in) / Schäfer, M. (Autor:in) / Baltschukat, K. (Autor:in) / Weisbrod, U. (Autor:in) / Micke, U. (Autor:in) / Facius, R. (Autor:in) / Bücker, H. (Autor:in)

    Erschienen in:

    Advances in Space Research ; 9 , 10 ; 105-116


    Erscheinungsdatum :

    1989-01-01


    Format / Umfang :

    12 pages




    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch




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