AbstractThe aim of this study is to investigate the effects of the clinostat-simulated microgravity on MCF-7 cells (a breast cancer cell line) biological characteristics. MCF-7 cells were incubated for 24h in an incubator and then rotated in a clinostat as a model of simulated microgravity for 24, 48 and 72h, respectively. The effects of the clinostat-simulated microgravity on MCF-7 cells proliferation, invasion, migration, gelatinase production, adhesion, cell cycle, apoptosis and vinculin expression were detected. The results showed that the clinostat-simulated microgravity affected breast cancer cell invasion, migration, adhesion, cell cycle, cell apoptosis and vinculin expression. These results may explore a new field of vision to study tumor metastasis in future.


    Zugriff

    Zugriff prüfen

    Verfügbarkeit in meiner Bibliothek prüfen

    Bestellung bei Subito €


    Exportieren, teilen und zitieren



    Titel :

    Simulated weightlessness alters biological characteristics of human breast cancer cell line MCF-7


    Beteiligte:
    Qian, Airong (Autor:in) / Zhang, Wei (Autor:in) / Xie, Li (Autor:in) / Weng, Yuanyuan (Autor:in) / Yang, Pengfei (Autor:in) / Wang, Zhe (Autor:in) / Hu, Lifang (Autor:in) / Xu, Huiyun (Autor:in) / Tian, Zongcheng (Autor:in) / Shang, Peng (Autor:in)

    Erschienen in:

    Acta Astronautica ; 63 , 7-10 ; 947-958


    Erscheinungsdatum :

    2008-01-26


    Format / Umfang :

    12 pages




    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch