AbstractThe aim of this study is to investigate the effects of the clinostat-simulated microgravity on MCF-7 cells (a breast cancer cell line) biological characteristics. MCF-7 cells were incubated for 24h in an incubator and then rotated in a clinostat as a model of simulated microgravity for 24, 48 and 72h, respectively. The effects of the clinostat-simulated microgravity on MCF-7 cells proliferation, invasion, migration, gelatinase production, adhesion, cell cycle, apoptosis and vinculin expression were detected. The results showed that the clinostat-simulated microgravity affected breast cancer cell invasion, migration, adhesion, cell cycle, cell apoptosis and vinculin expression. These results may explore a new field of vision to study tumor metastasis in future.
Simulated weightlessness alters biological characteristics of human breast cancer cell line MCF-7
Acta Astronautica ; 63 , 7-10 ; 947-958
2008-01-26
12 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
Simulated microgravity , Breast cancer , Invasion , Adhesion , Cell cycle , Apoptosis , ECM , extracellular matrix , FCS , fetal calf serum , PI , propidum iodide , DI , DNA index , MMPs , matrix metalloproteinase , FN , fibronectin , LN , laminin , Col , collagen
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