Incomplete combustion process is a potential source ofbenzo(a)pyrene (BaP) and tetrachlorodibenzo-p-dioxin(TCDD ). These compounds have been detected in effluents ofmunicipal incinerators, sewage sludge, cigarette smoke, automobileexhaust etc. Although BaP and TCD have carcinogenicpotential, in recent years these agents have received great attentiondue to their environmental persistence and remarkablyacute toxicity.To assess health risks associated with human exposure toBaP and TCDD, it was of interest to evaluate their effects uponhuman polymorphonuclear leucocytes by measuring the releaseof lysosomal and cytoplasmic enzymes.Suspensions of human polymorphonuclear leucocytes(PMNL) were treated with BaP, TCDD and BaP+ TCDD atconcentrations of 1 0·1, 1 Q-6M. These agents provoked a progressivetime- and dose-dependent release of lysosomal enzymebeta-N-acetyl-glucosaminidase and cytoplasmic enzyme lactate dehydrogenase, beta-GLM and LDH respectively. Atconcentrations listed TCDD was much more effective in realisingboth enzymes beta -G LM and LDH than BaP. In the experimentswith the combination of BaP+ TCDD, extracellular releaseof beta-GLM or LDH was significantly higher as comparedto BaP or TCDD-treated samples. lt seems possible thatTCDD affected the solubility of beta-GLM and LDH to agreater extent than the activity of BaP.The observations obtained in these studies suggest that BaPand TCDD damage the lysosomal and cellular membranes.


    Zugriff

    Download


    Exportieren, teilen und zitieren



    Titel :

    The Effects of Benzo(a)pyrene and 2, 3, 7, 8-Tetrachlorodibenzo-p-diox:in from Automobile Exhaust...


    Beteiligte:
    Olga Carević (Autor:in)


    Erscheinungsdatum :

    2012




    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Elektronische Ressource


    Sprache :

    Unbekannt




    Benzo (a) pyrene Emissions from Gasoline and Diesel Automobiles

    Williams, R. L. / Swarin, S. J. | SAE Technical Papers | 1979


    Benzo (a) pyrene emissions from gasoline and Diesel automobiles

    Williams,R.L. / Swarin,S.J. / General Motors,US | Kraftfahrwesen | 1979


    Screening technique to estimate high benzo[a]pyrene concentrations near roads

    Kondo, Akira / Hazama, Toshiro / Shimadera, Hikari et al. | Tema Archiv | 2012


    Automobile exhaust monitoring device

    ZHANG BAIYUN / ZHANG ZHONGSHENG | Europäisches Patentamt | 2022

    Freier Zugriff

    Automobile exhaust sound generator

    YANG SUNG JIN | Europäisches Patentamt | 2019

    Freier Zugriff