Neural interfaces for neuroscientific research are nowadays mainly manufactured using standard microsystems engineering technologies which are incompatible with the integration of carbon as electrode material. In this work, we investigate a new method to fabricate graphitic carbon electrode arrays on flexible substrates. The devices were manufactured using infrared nanosecond laser technology for both patterning all components and carbonizing the electrode sites. Two laser pulse repetition frequencies were used for carbonization with the aim of finding the optimum. Prototypes of the devices were evaluated in vitro in 30 mM hydrogen peroxide to mimic the post-surgery oxidative environment. The electrodes were subjected to 10 million biphasic pulses (39.5 [my]C/cm2) to measure their stability under electrical stress. Their biosensing capabilities were evaluated in different concentrations of dopamine in phosphate buffered saline solution. Raman spectroscopy and x-ray photoelectron spectroscopy analysis show that the atomic percentage of graphitic carbon in the manufactured electrodes reaches the remarkable value of 75%. Results prove that the infrared nanosecond laser yields activated graphite electrodes that are conductive, non-cytotoxic and electrochemically inert. Their comprehensive assessment indicates that our laser-induced carbon electrodes are suitable for future transfer into in vivo studies, including neural recordings, stimulation and neurotransmitters detection.


    Zugriff

    Download


    Exportieren, teilen und zitieren



    Titel :

    Graphitic carbon electrodes on flexible substrate for neural applications entirely fabricated using infrared nanosecond laser technology


    Beteiligte:
    Vomero, Maria (Autor:in) / Oliveira, Ana (Autor:in) / Ashouri, Danesh (Autor:in) / Eickenscheidt, Max (Autor:in) / Stieglitz, Thomas (Autor:in)

    Erscheinungsdatum :

    2018-01-01



    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch



    Klassifikation :

    DDC:    620 / 629



    MnO2-coated graphitic petals for supercapacitor electrodes

    Xiong, Guoping | Online Contents | 2013


    Nanosecond Laser Imaging

    Packard, John N. | IEEE | 1966


    An entirely electrically welded vessel

    Engineering Index Backfile | 1921


    Laser-induced transparency during nanosecond laser ablation

    Andreev, S. N. / Samokhin, A. A. / Kartashov, I. N. et al. | SPIE | 2003


    Entirely new Austin ten-four

    Engineering Index Backfile | 1932