One of the main goals in neuroscience is to understand the underlying neural circuit that governs behavior. Thanks to recent advances in experimental approaches and new technologies, we are a step closer to answering this question. One of the main promising approaches is to look directly into the brain in vivo. By using two-photon microscopy and genetically encoded calcium indicators, it is now possible to longitudinally observe the dynamics of neuronal networks in awake behaving animals under head-fixed conditions. Additionally mice can be exposed to a myriad of virtual realities that provides them with more realistic conditions in which they can control sensory stimuli. Neural recordings in head-restrained but behaving animals allow us to present controlled and realistic stimuli as well as simultaneous measurements of behavioral variables. Consequently this leads to better understanding of neural correlates of behavior and stimulus. In my thesis, I use a novel tactile virtual reality setup in which animals were freely running and whisking along a wall. I measured neural activity of different neural populations particularly in somatosensory cortex as well as hippocampus to understand how brain codes information under different motor states such as locomotion.


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    Titel :

    Tactile Virtual Reality Setup to Study Functional Neuronal Subtypes in Barrel Cortex and Dentate Gyrus


    Beteiligte:

    Erscheinungsdatum :

    2019-01-01


    Anmerkungen:

    doi:10.5167/uzh-213078
    Stäuble, Andreas. Tactile Virtual Reality Setup to Study Functional Neuronal Subtypes in Barrel Cortex and Dentate Gyrus. 2019, University of Zurich, Faculty of Science.



    Medientyp :

    Hochschulschrift


    Format :

    Elektronische Ressource


    Sprache :

    Englisch



    Klassifikation :

    DDC:    629



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