Microfluidic flow-based biochips are taking the place of conventional biological laboratories by using their microfluidic very large scale integration technology. Manual design procedures are still the mainstream in the present, but they are hard to be applied to complex experimental design. At present, researches of matrix-based biochip automation are relatively less so that the design automation for control layer in the matrix-based biochip has not realized. In this work, we present a computer-aided design for control layer in the matrix-based continuous-flow mircofluidic biochip to improve the routability of valves and reduce the count of ports, which cannot be supported by previous work. We first introduce the control channel routing problem for matrix-based biochip and then propose an integer-linear-programming (ILP) model for solving this problem. In this model, we use the characteristics of working pattern to implement that multiple valves can be connected with control channels to one port. Therefore, the goals of our design can be achieved.
Control Channel Routing for Matrix-Based Continuous-Flow Microfluidic Biochips
2019-12-03
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
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