Human behaviour requires flexible arbitration between actions we do out of habit and actions that are directed towards a specific goal. Drugs that target opioid and dopamine receptors are notorious for inducing maladaptive habitual drug consumption; yet, how the opioidergic and dopaminergic neurotransmitter systems contribute to the arbitration between habitual and goal-directed behaviour is poorly understood. By combining pharmacological challenges with a well-established decision-making task and a novel computational model, we show that the administration of the dopamine D2/3 receptor antagonist amisulpride led to an increase in goal-directed or 'model-based' relative to habitual or 'model-free' behaviour, whereas the non-selective opioid receptor antagonist naltrexone had no appreciable effect. The effect of amisulpride on model-based/model-free behaviour did not scale with drug serum levels in the blood. Furthermore, participants with higher amisulpride serum levels showed higher explorative behaviour. These findings highlight the distinct functional contributions of dopamine and opioid receptors to goal-directed and habitual behaviour and support the notion that even small doses of amisulpride promote flexible application of cognitive control.


    Zugriff

    Download


    Exportieren, teilen und zitieren



    Titel :

    Effects of dopamine D2/3 and opioid receptor antagonism on the trade-off between model-based and model-free behaviour in healthy volunteers


    Beteiligte:
    Mikus, Nace (Autor:in) / Korb, Sebastian (Autor:in) / Massaccesi, Claudia (Autor:in) / Gausterer, Christian (Autor:in) / Graf, Irene (Autor:in) / Willeit, Matthäus (Autor:in) / Eisenegger, Christoph (Autor:in) / Lamm, Claus (Autor:in) / Silani, Giorgia (Autor:in) / Mathys, Christoph (Autor:in)

    Erscheinungsdatum :

    2022-12-01


    Anmerkungen:

    Mikus , N , Korb , S , Massaccesi , C , Gausterer , C , Graf , I , Willeit , M , Eisenegger , C , Lamm , C , Silani , G & Mathys , C 2022 , ' Effects of dopamine D2/3 and opioid receptor antagonism on the trade-off between model-based and model-free behaviour in healthy volunteers ' , eLife , vol. 11 , e79661 . https://doi.org/10.7554/eLife.79661



    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch



    Klassifikation :

    DDC:    629



    Simulated Hypergravity Activates Hemostasis in Healthy Volunteers

    Limper, U. / Ahnert, T. / Maegele, M. et al. | Deutsches Zentrum für Luft- und Raumfahrt (DLR) | 2020

    Freier Zugriff

    Cognitive and Driving Performance Effects of Nefazodone and Imipramine in Healthy Volunteers

    Van Laar, M. W. / Volkerts, E. R. / University of Adelaide; NHMRC Road Accident Research Unit | British Library Conference Proceedings | 1995


    Effect of Terbinafine on Desipramine Metabolism in Healthy Volunteers

    Madani, S. / Barilla, D. / Cramer, J. et al. | British Library Conference Proceedings | 2002


    P.2.072 Pharmacokinetics of intramuscular (IM) ziprasidone in healthy volunteers

    Miceli, J. J. / Wilner, K. D. / Tensfeldt, T. G. et al. | British Library Conference Proceedings | 2001