For more than 20 years, robotic bioreactor systems have facilitated the growth of tissue-engineered constructs using mechanical stimulation. However, we are still unable to produce functional grafts that can translate into clinical use. Humanoid robots offer the prospect of providing physiologically-relevant mechanical stimulation to grafts and implants which may expedite their clinical deployment. To investigate the feasibility of a humanoid bioreactor, we have designed a flexible bioreactor chamber that can be attached to a modified musculoskeletal (MSK) humanoid robot shoulder joint. We demonstrate that fibroblast cells can be grown in this chamber while undergoing physiological adduction-abduction on the robotic arm. A preliminary evaluation of the transcriptome of the cells after 14 days indicated a clear influence of the loading regime on the gene expression profile. These early results will facilitate the exploration of MSK humanoid robots as a biomechanically more realistic platform for tissue engineering and biomaterial testing applications.


    Zugriff

    Download


    Exportieren, teilen und zitieren



    Titel :

    Humanoid robots to mechanically stress human cells grown in soft bioreactors


    Beteiligte:
    Mouthuy, P-A (Autor:in) / Snelling, S (Autor:in) / Hostettler, R (Autor:in) / Kharchenko, A (Autor:in) / Salmon, S (Autor:in) / Wainman, A (Autor:in) / Mimpen, J (Autor:in) / Paul, C (Autor:in) / Carr, A (Autor:in)

    Erscheinungsdatum :

    2022-05-27



    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch


    Klassifikation :

    DDC:    629



    Humanoid Robots

    Choi, Ben | GWLB - Gottfried Wilhelm Leibniz Bibliothek | 2009

    Freier Zugriff

    Humanoid Robots

    Choi, Ben | TIBKAT | 2009

    Freier Zugriff

    Humanoid Robots : New Developments

    Carlos de Pina Filho, Armando | TIBKAT | 2007

    Freier Zugriff

    Humanoid Robots for Entertainment

    Silverstein, Steven “Mouse” / Yamane, Katsu | Springer Verlag | 2018


    Collaborative and Humanoid Robots

    Hamilton Ortiz, Jesús ;Kumar Vinjamuri, Ramana | GWLB - Gottfried Wilhelm Leibniz Bibliothek | 2021

    Freier Zugriff